How Does Ultram Work?

Ultram's success as a pain killer arises from the fact that it resembles codeine in the sense that

it is an opiate. This drug binds to the brain's opioid receptors, which is a portion of the DNA

sequence where scientists discovered morphine attaches to the gene. Because morphine is a product of opium, the receptors became known as “opioids”. These opioid receptors let the

body know when it feels pain, whether in the brain or in organs. Synthetically created, Ultram

changes how the body feels pain. Although it reduces pain, Ultram is not a nonsteroidal antiinflammatory

drug (NSAID), like aspirin or ibuprofen.

One result of Ultram usage is the release of serotonin, which is a neurotransmitter that scientists

believe regulates sleep, mood and appetite. In other words, the patient who takes Ultram may

feel happier or in a better mood. Another result with Ultram usage is that it interferes with the

brain's realization that the body has released norepinephrine, the stress hormone responsible

for the flight-or-fight response of animals. The release of norepinephrine causes an increase of

glucose and blood flow in the blood stream, and a faster heart rate. This gives the body extra

energy. Ultram slows down the release of these hormones, leading the body into believing the

pain experienced doesn't actually exist.


A third aspect of Ultram is that it reduces the speed of the brain's 5-HT2C receptors, which is

where serotonin is located. This means that feelings of depression or anxiety that can happen

when a patient experiences pain, may be reduced by Ultram, creating a more comfortable patient.

The most important result from taking Ultram is that pain is reduced without any accompanying

feeling of being dazed or drugged. Any patient taking Ultram who feels excessive drowsiness,

headaches or stomach cramping should inform a physician immediately (See Ultram Side Effects

in a section below).


Common Ultram Dosage


The amount of Ultram prescribed most often by doctors is 50 milligrams in the form of

immediate release pills, which are taken every four to six hours. There is a maximum of 400

milligrams in one 24-hour time frame. To control the possible side effects of Ultram, doctors

frequently prescribe a beginning dose of 25 milligrams, to be taken once every day. At the end of

three days, doctors may increase the dosage to two 25-milligram pills per day. If no side effects

are experienced, the number of 25-milligram pills increases to three at the beginning of the

seventh day.

Strength Quantity Price  
50mg 60 Pills $101.40 Buy
50mg 120 Pills $170.40 Buy
50mg 180 Pills $190.80 Buy

After the patient reaches 200 milligrams of the drug in a day, a medical professional should

monitor the patient to make sure he or she doesn’t experience addiction to Ultram. Because of

the potential for addiction, the dosage should not exceed 300 milligrams every day.


If started with a low dosage that increases gradually, adults tend to experience fewer side effects.

Beginning at a lower dosage also allows the patient to reach the proper amount that best controls

the pain. People over 65 years of age should begin taking Ultram in low doses. For patients over 75 years of age, Ultram should never be taken in a dose of more than 300 milligrams daily.

Ultram causes gastrointestinal problems in approximately 17 percent of patients over 65, and

approximately 30 percent of people over 75. For about 10 percent of people over 75, constipation

becomes a serious enough issue that they have to stop using Ultram.


With a dosage of 400 milligrams daily, serious and possibly fatal side effects can occur. Fatality

can occur if a one-time dose of Ultram in the range of 300 milligrams is taken, without prior

buildup in the system. Deaths linked to daily dosages of around 500 to 1,000 milligrams have

been documented.


People with kidney or liver problems should remain on low dosages of Ultram. Patients younger

than 16 should not use Ultram. Only the person with the prescription should take this drug.

Ultram is not meant to be shared with others. Also, Ultram should not be taken at a later time for

a condition other than it was prescribed for, because of the chance of side effects. Use caution if

taking Ultram with other drugs. For more information, see Ultram Side Effects discussed below.